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Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding.

The L-21 Sca I ribozyme derived from the group I intron of Tetrahymena thermophila pre-rRNA catalyzes an endonuclease reaction analogous to the first step of self-splicing. Guanosine (G) is bound by the ribozyme, and its 3'-hydroxyl group acts as the nucleophile. Here, we provide evidence that...

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Bibliografiske detaljer
Main Authors: McConnell, T S, Cech, T R, Herschlag, D
Format: Artigo
Sprog:Inglês
Udgivet: 1993
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC47356/
https://ncbi.nlm.nih.gov/pubmed/8378306
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