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Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes
BACKGROUND: We have previously shown that non-equilibrium Na(+) current (I(Na)) reactivation drives isoproterenol-induced phase-3 early afterdepolarizations (EADs) in mouse ventricular myocytes. In these cells, EAD initiation occurs secondary to potentiated sarcoplasmic reticulum Ca(2+) release and...
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| Publicado no: | J Mol Cell Cardiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4734906/ https://ncbi.nlm.nih.gov/pubmed/26241847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.07.030 |
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