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A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na(+) loading and CaMKII
Ca(2+)–calmodulin-dependent protein kinase II (CaMKII) hyperactivity in heart failure causes intracellular Na(+) ([Na(+)](i)) loading (at least in part by enhancing the late Na(+) current). This [Na(+)](i) gain promotes intracellular Ca(2+) ([Ca(2+)](i)) overload by altering the equilibrium of the N...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell publishing Ltd
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3961080/ https://ncbi.nlm.nih.gov/pubmed/24421356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.266676 |
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