A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na(+) loading and CaMKII

Ca(2+)–calmodulin-dependent protein kinase II (CaMKII) hyperactivity in heart failure causes intracellular Na(+) ([Na(+)](i)) loading (at least in part by enhancing the late Na(+) current). This [Na(+)](i) gain promotes intracellular Ca(2+) ([Ca(2+)](i)) overload by altering the equilibrium of the N...

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Bibliografske podrobnosti
Main Authors: Morotti, S, Edwards, A G, McCulloch, A D, Bers, D M, Grandi, E
Format: Artigo
Jezik:Inglês
Izdano: Blackwell publishing Ltd 2014
Teme:
Computational Physiology and Modelling
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961080/
https://ncbi.nlm.nih.gov/pubmed/24421356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.266676
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