Non-equilibrium reactivation of Na(+) current drives early afterdepolarizations in mouse ventricle

BACKGROUND: Early-afterdepolarizations (EADs) are triggers of cardiac arrhythmia driven by L-type Ca(2+) current (I(Ca(L))) reactivation or sarcoplasmic reticulum (SR) Ca(2+) release and Na(+)/Ca(2+) exchange. In large mammals the positive action potential (AP) plateau promotes I(Ca(L)) reactivation...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Circ Arrhythm Electrophysiol
Egile Nagusiak: Edwards, Andrew G., Grandi, Eleonora, Hake, Johan E., Patel, Sonia, Li, Pan, Miyamoto, Shigeki, Omens, Jeffrey H., Brown, Joan Heller, Bers, Donald M., McCulloch, Andrew D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301603/
https://ncbi.nlm.nih.gov/pubmed/25236710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.113.001666
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