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Non-equilibrium reactivation of Na(+) current drives early afterdepolarizations in mouse ventricle
BACKGROUND: Early-afterdepolarizations (EADs) are triggers of cardiac arrhythmia driven by L-type Ca(2+) current (I(Ca(L))) reactivation or sarcoplasmic reticulum (SR) Ca(2+) release and Na(+)/Ca(2+) exchange. In large mammals the positive action potential (AP) plateau promotes I(Ca(L)) reactivation...
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| Publicado no: | Circ Arrhythm Electrophysiol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301603/ https://ncbi.nlm.nih.gov/pubmed/25236710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.113.001666 |
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