Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations

Sarcoplasmic reticulum (SR) Ca(2+) release mediates excitation–contraction coupling (ECC) in cardiac myocytes. It is triggered upon membrane depolarization by entry of Ca(2+) via L-type Ca(2+) channels (LTCCs), which undergo both voltage- and Ca(2+)-dependent inactivation (VDI and CDI, respectively)...

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Main Authors: Morotti, Stefano, Grandi, Eleonora, Summa, Aurora, Ginsburg, Kenneth S, Bers, Donald M
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2012
Teme:
Computational Physiology and Modelling
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477752/
https://ncbi.nlm.nih.gov/pubmed/22586219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.231886
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