Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

BACKGROUND: We have previously shown that non-equilibrium Na(+) current (I(Na)) reactivation drives isoproterenol-induced phase-3 early afterdepolarizations (EADs) in mouse ventricular myocytes. In these cells, EAD initiation occurs secondary to potentiated sarcoplasmic reticulum Ca(2+) release and...

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Publicat a:J Mol Cell Cardiol
Autors principals: Morotti, Stefano, McCulloch, Andrew D., Bers, Donald M., Edwards, Andrew G., Grandi, Eleonora
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734906/
https://ncbi.nlm.nih.gov/pubmed/26241847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.07.030
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