Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells

Nef-specific CD8(+) T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B*017:01-restricted Nef(165–173)IW9 epitope revealed highly restricted evolution....

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Weiler, Andrea M., Das, Arpita, Akinyosoye, Oluwasayo, Cui, Sherry, O'Connor, Shelby L., Scheef, Elizabeth A., Reed, Jason S., Panganiban, Antonito T., Sacha, Jonah B., Rakasz, Eva G., Friedrich, Thomas C., Maness, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733980/
https://ncbi.nlm.nih.gov/pubmed/26637459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01975-15
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