Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells

Nef-specific CD8(+) T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B*017:01-restricted Nef(165–173)IW9 epitope revealed highly restricted evolution....

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Weiler, Andrea M., Das, Arpita, Akinyosoye, Oluwasayo, Cui, Sherry, O'Connor, Shelby L., Scheef, Elizabeth A., Reed, Jason S., Panganiban, Antonito T., Sacha, Jonah B., Rakasz, Eva G., Friedrich, Thomas C., Maness, Nicholas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733980/
https://ncbi.nlm.nih.gov/pubmed/26637459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01975-15
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