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Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3
Lentiviral Nefs recruit assembly polypeptide complexes and target sorting motifs in cellular receptors to induce their internalization. While Nef-mediated CD4 downmodulation is conserved, the ability to internalize CD3 was lost in HIV-1 and its precursors. Although both functions play key roles in l...
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| 發表在: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5585231/ https://ncbi.nlm.nih.gov/pubmed/28874665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00481-z |
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