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Comparison of Strategies for Non-perturbing Labeling of α-Synuclein to Study Amyloidogenesis

Characterization of the amyloidogenic Parkinson’s Disease protein α-synuclein (αS) has proven difficult due to its structural plasticity. Here, we present a number of complementary methods to site-specifically introduce fluorescent probes to examine αS fibril formation and cellular uptake. By using...

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Библиографические подробности
Опубликовано в: :Org Biomol Chem
Главные авторы: Haney, Conor M., Wissner, Rebecca F., Warner, John B., Wang, Yanxin J., Ferrie, John J., Covell, Dustin, Karpowicz, Richard J., Lee, Virginia M.-Y., Petersson, E. James
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733880/
https://ncbi.nlm.nih.gov/pubmed/26695131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob02329g
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