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Native Chemical Ligation of Thioamide-Containing Peptides: Development and Application to the Synthesis of Labeled α-Synuclein for Misfolding Studies

Thioamide modifications of the peptide backbone are used to perturb secondary structure, to inhibit proteolysis, as photoswitches, and as spectroscopic labels. Thus far, their incorporation has been confined to single peptides synthesized on solid phase. We have generated thioamides in C-terminal th...

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Bibliografiska uppgifter
Huvudupphovsmän: Batjargal, Solongo, Wang, Yanxin J., Goldberg, Jacob M., Wissner, Rebecca F., Petersson, E. James
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415603/
https://ncbi.nlm.nih.gov/pubmed/22468862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2113245
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