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Native Chemical Ligation of Thioamide-Containing Peptides: Development and Application to the Synthesis of Labeled α-Synuclein for Misfolding Studies

Thioamide modifications of the peptide backbone are used to perturb secondary structure, to inhibit proteolysis, as photoswitches, and as spectroscopic labels. Thus far, their incorporation has been confined to single peptides synthesized on solid phase. We have generated thioamides in C-terminal th...

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Bibliografiske detaljer
Main Authors: Batjargal, Solongo, Wang, Yanxin J., Goldberg, Jacob M., Wissner, Rebecca F., Petersson, E. James
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415603/
https://ncbi.nlm.nih.gov/pubmed/22468862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2113245
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