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Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies

Direct cell-to-cell transmission of proteopathic α-synuclein (α-syn) aggregates is thought to underlie the progression of neurodegenerative synucleinopathies. However, the specific intracellular processes governing this transmission remain unclear because currently available model systems are limite...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Karpowicz, Richard J., Haney, Conor M., Mihaila, Tiberiu S., Sandler, Raizel M., Petersson, E. James, Lee, Virginia M.-Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555207/
https://ncbi.nlm.nih.gov/pubmed/28611062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.780296
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