SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition

The expansion of fat mass in the obese state is due to increased adipocyte hypertrophy and hyperplasia. The molecular mechanism that drives adipocyte hyperplasia remains unknown. The NAD(+)-dependent protein deacetylase sirtuin 1 (SIRT1), a key regulator of mammalian metabolism, maintains proper met...

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Udgivet i:J Biol Chem
Main Authors: Abdesselem, Houari, Madani, Aisha, Hani, Ahmad, Al-Noubi, Muna, Goswami, Neha, Ben Hamidane, Hisham, Billing, Anja M., Pasquier, Jennifer, Bonkowski, Michael S., Halabi, Najeeb, Dalloul, Rajaa, Sheriff, Mohamed Z., Mesaeli, Nasrin, ElRayess, Mohamed, Sinclair, David A., Graumann, Johannes, Mazloum, Nayef A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732199/
https://ncbi.nlm.nih.gov/pubmed/26655722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.675645
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