SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways

The NAD(+)-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or NAD(+) boosters alleviate metabolic complications. We previously reported that SIRT1-depletion in 3T3-L1 preadipocytes l...

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Vydáno v:Sci Rep
Hlavní autoři: Majeed, Yasser, Halabi, Najeeb, Madani, Aisha Y., Engelke, Rudolf, Bhagwat, Aditya M., Abdesselem, Houari, Agha, Maha V., Vakayil, Muneera, Courjaret, Raphael, Goswami, Neha, Hamidane, Hisham Ben, Elrayess, Mohamed A., Rafii, Arash, Graumann, Johannes, Schmidt, Frank, Mazloum, Nayef A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046990/
https://ncbi.nlm.nih.gov/pubmed/33854178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87759-x
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