SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways

The NAD(+)-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or NAD(+) boosters alleviate metabolic complications. We previously reported that SIRT1-depletion in 3T3-L1 preadipocytes l...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Majeed, Yasser, Halabi, Najeeb, Madani, Aisha Y., Engelke, Rudolf, Bhagwat, Aditya M., Abdesselem, Houari, Agha, Maha V., Vakayil, Muneera, Courjaret, Raphael, Goswami, Neha, Hamidane, Hisham Ben, Elrayess, Mohamed A., Rafii, Arash, Graumann, Johannes, Schmidt, Frank, Mazloum, Nayef A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046990/
https://ncbi.nlm.nih.gov/pubmed/33854178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87759-x
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