The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action

Staphylococcus aureus uses the two-component regulatory system GraRS to sense and respond to host defense peptides (HDPs). However, the mechanistic impact of GraS or its extracellular sensing loop (EL) on HDP resistance is essentially unexplored. Strains with null mutations in the GraS holoprotein (...

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Publicat a:Infect Immun
Autors principals: Chaili, Siyang, Cheung, Ambrose L., Bayer, Arnold S., Xiong, Yan Q., Waring, Alan J., Memmi, Guido, Donegan, Niles, Yang, Soo-Jin, Yeaman, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Bacterial Infections
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730570/
https://ncbi.nlm.nih.gov/pubmed/26597988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01030-15
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