The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action

Staphylococcus aureus uses the two-component regulatory system GraRS to sense and respond to host defense peptides (HDPs). However, the mechanistic impact of GraS or its extracellular sensing loop (EL) on HDP resistance is essentially unexplored. Strains with null mutations in the GraS holoprotein (...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Infect Immun
Main Authors: Chaili, Siyang, Cheung, Ambrose L., Bayer, Arnold S., Xiong, Yan Q., Waring, Alan J., Memmi, Guido, Donegan, Niles, Yang, Soo-Jin, Yeaman, Michael R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Bacterial Infections
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730570/
https://ncbi.nlm.nih.gov/pubmed/26597988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01030-15
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