The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action

Staphylococcus aureus uses the two-component regulatory system GraRS to sense and respond to host defense peptides (HDPs). However, the mechanistic impact of GraS or its extracellular sensing loop (EL) on HDP resistance is essentially unexplored. Strains with null mutations in the GraS holoprotein (...

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Bibliografische gegevens
Gepubliceerd in:Infect Immun
Hoofdauteurs: Chaili, Siyang, Cheung, Ambrose L., Bayer, Arnold S., Xiong, Yan Q., Waring, Alan J., Memmi, Guido, Donegan, Niles, Yang, Soo-Jin, Yeaman, Michael R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2016
Onderwerpen:
Bacterial Infections
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4730570/
https://ncbi.nlm.nih.gov/pubmed/26597988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01030-15
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