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Tumor-associated MUC1 glycopeptide epitopes are not subject to self-tolerance and improve responses to MUC1 peptide epitopes in MUC1 transgenic mice

Human adenocarcinomas overexpress a hypoglycosylated, tumor-associated form of the mucin-like glycoprotein MUC1 containing abnormal mono- and disaccharide antigens, such as Tn, sialyl-Tn, and TF, as well as stretches of unglycosylated protein backbone in the variable number of tandem repeats (VNTR)...

Полное описание

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Библиографические подробности
Опубликовано в: :Biol Chem
Главные авторы: Ryan, Sean O., Vlad, Anda M., Islam, Kazi, Gariépy, Jean, Finn, Olivera J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729297/
https://ncbi.nlm.nih.gov/pubmed/19426130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/BC.2009.070
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