Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli

Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is responsible for reducing all four ribonucleotide substrates, with specificity regulated by the binding of an effector to a distal allosteric s...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Zimanyi, Christina M, Chen, Percival Yang-Ting, Kang, Gyunghoon, Funk, Michael A, Drennan, Catherine L
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2016
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728125/
https://ncbi.nlm.nih.gov/pubmed/26754917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07141
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