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Disruption of an oligomeric interface prevents allosteric inhibition of Escherichia coli class Ia ribonucleotide reductase

Ribonucleotide reductases (RNRs) convert ribonucleotides to deoxynucleotides, a process essential for DNA biosynthesis and repair. Class Ia RNRs require two dimeric subunits for activity: an α(2) subunit that houses the active site and allosteric regulatory sites and a β(2) subunit that houses the d...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Chen, Percival Yang-Ting, Funk, Michael A., Brignole, Edward J., Drennan, Catherine L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028975/
https://ncbi.nlm.nih.gov/pubmed/29700111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002569
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