Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase

Acetylation of α-tubulin Lys40 by tubulin acetyltransferase (TAT) is the only known posttranslational modification in the microtubule lumen. It marks stable microtubules and is required for polarity establishment and directional migration. Here we elucidate the mechanistic underpinnings for TAT acti...

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Udgivet i:Cell
Main Authors: Szyk, Agnieszka, Deaconescu, Alexandra M., Spector, Jeffrey, Goodman, Benjamin, Valenstein, Max L., Ziolkowska, Natasza E., Kormendi, Vasilisa, Grigorieff, Nikolaus, Roll-Mecak, Antonina
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726456/
https://ncbi.nlm.nih.gov/pubmed/24906155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.061
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