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Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin

Tubulin tyrosine ligase (TTL) catalyzes the post-translational C-terminal tyrosination of α–tubulin. Tyrosination regulates recruitment of microtubule interacting proteins. TTL is essential. Its loss causes morphogenic abnormalities and is associated with cancers of poor prognosis. We present the fi...

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Detalhes bibliográficos
Main Authors: Szyk, Agnieszka, Deaconescu, Alexandra M., Piszczek, Grzegorz, Roll-Mecak, Antonina
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342691/
https://ncbi.nlm.nih.gov/pubmed/22020298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2148
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