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Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin

Tubulin tyrosine ligase (TTL) catalyzes the post-translational C-terminal tyrosination of α–tubulin. Tyrosination regulates recruitment of microtubule interacting proteins. TTL is essential. Its loss causes morphogenic abnormalities and is associated with cancers of poor prognosis. We present the fi...

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Sonraí Bibleagrafaíochta
Main Authors: Szyk, Agnieszka, Deaconescu, Alexandra M., Piszczek, Grzegorz, Roll-Mecak, Antonina
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342691/
https://ncbi.nlm.nih.gov/pubmed/22020298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2148
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