Rational steering of insulin binding specificity by intra-chain chemical crosslinking

Insulin is a key hormone of human metabolism with major therapeutic importance for both types of diabetes. New insulin analogues with more physiological profiles and better glycemic control are needed, especially analogues that preferentially bind to the metabolic B-isoform of insulin receptor (IR-B...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Viková, Jitka, Collinsová, Michaela, Kletvíková, Emília, Buděšínský, Miloš, Kaplan, Vojtěch, Žáková, Lenka, Veverka, Václav, Hexnerová, Rozálie, Aviñó, Roberto J. Tarazona, Straková, Jana, Selicharová, Irena, Vaněk, Václav, Wright, Daniel W., Watson, Christopher J., Turkenburg, Johan P., Brzozowski, Andrzej M., Jiráček, Jiří
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726324/
https://ncbi.nlm.nih.gov/pubmed/26792393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19431
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi