Rational steering of insulin binding specificity by intra-chain chemical crosslinking

Insulin is a key hormone of human metabolism with major therapeutic importance for both types of diabetes. New insulin analogues with more physiological profiles and better glycemic control are needed, especially analogues that preferentially bind to the metabolic B-isoform of insulin receptor (IR-B...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Viková, Jitka, Collinsová, Michaela, Kletvíková, Emília, Buděšínský, Miloš, Kaplan, Vojtěch, Žáková, Lenka, Veverka, Václav, Hexnerová, Rozálie, Aviñó, Roberto J. Tarazona, Straková, Jana, Selicharová, Irena, Vaněk, Václav, Wright, Daniel W., Watson, Christopher J., Turkenburg, Johan P., Brzozowski, Andrzej M., Jiráček, Jiří
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726324/
https://ncbi.nlm.nih.gov/pubmed/26792393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19431
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