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Natural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C-terminal helix α(18)
High replicative fitness is a general determinant of a multidrug resistance phenotype and may explain lower sensitivity to direct-acting antiviral agents (DAAs) in some hepatitis C virus genotypes. Genetic diversity in the molecular target site of peptidomimetic NS3 protease inhibitors could impact...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4726148/ https://ncbi.nlm.nih.gov/pubmed/26787124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19526 |
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