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A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance

Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism m...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Tomlinson, Jennifer H., Thompson, Gary S., Kalverda, Arnout P., Zhuravleva, Anastasia, O’Neill, Alex J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725979/
https://ncbi.nlm.nih.gov/pubmed/26781961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19524
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