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Stabilizing Off-pathway Oligomers by Polyphenol Nanoassemblies for IAPP Aggregation Inhibition

Experimental studies have shown that many naturally occurring polyphenols have inhibitory effect on the aggregation of several proteins. Here, we use discrete molecular dynamics (DMD) simulations and high-throughput dynamic light scattering (DLS) experiments to study the anti-aggregation effects of...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Nedumpully-Govindan, Praveen, Kakinen, Aleksandr, Pilkington, Emily H., Davis, Thomas P., Chun Ke, Pu, Ding, Feng
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725907/
https://ncbi.nlm.nih.gov/pubmed/26763863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19463
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