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Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation
Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion molecular complex with C-p...
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| 出版年: | Chem Commun (Camb) |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5570498/ https://ncbi.nlm.nih.gov/pubmed/28745731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc04291d |
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