Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion molecular complex with C-p...

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Publicado en:Chem Commun (Camb)
Autores principales: Ge, Xinwei, Kakinen, Aleksandr, Gurzov, Esteban N., Yang, Wen, Pang, Lokman, Pilkington, Emily H., Govindan-Nedumpully, Praveen, Chen, Pengyu, Separovic, Frances, Davis, Thomas P., Ke, Pu Chun, Ding, Feng
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570498/
https://ncbi.nlm.nih.gov/pubmed/28745731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc04291d
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