Effects of Protein Corona on IAPP Amyloid Aggregation, Fibril Remodelling, and Cytotoxicity

Aggregation of islet amyloid polypeptide (IAPP), a peptide hormone co-synthesized and co-stored with insulin in pancreatic cells and also co-secreted to the circulation, is associated with beta-cell death in type-2 diabetes (T2D). In T2D patients IAPP is found aggregating in the extracellular space...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pilkington, Emily H., Xing, Yanting, Wang, Bo, Kakinen, Aleksandr, Wang, Miaoyi, Davis, Thomas P., Ding, Feng, Ke, Pu Chun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446405/
https://ncbi.nlm.nih.gov/pubmed/28550295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02597-0
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