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Structural variants of yeast prions show conformer-specific requirements for chaperone activity

Molecular chaperones monitor protein homeostasis and defend against the misfolding and aggregation of proteins that is associated with protein conformational disorders. In these diseases, a variety of different aggregate structures can form. These are called prion strains, or variants, in prion dise...

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Bibliographic Details
Published in:Mol Microbiol
Main Authors: Stein, Kevin C., True, Heather L.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725586/
https://ncbi.nlm.nih.gov/pubmed/25060529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12725
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