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Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic Regions

Amyloidogenic proteins associated with a variety of unrelated diseases are typically capable of forming several distinct self-templating conformers. In prion diseases, these different structures, called prion strains (or variants), confer dramatic variation in disease pathology and transmission. Agg...

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書誌詳細
主要な著者: Stein, Kevin C., True, Heather L.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014422/
https://ncbi.nlm.nih.gov/pubmed/24811344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004337
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