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Spontaneous Variants of the [RNQ+] Prion in Yeast Demonstrate the Extensive Conformational Diversity Possible with Prion Proteins

Prion strains (or variants) are structurally distinct amyloid conformations arising from a single polypeptide sequence. The existence of prion strains has been well documented in mammalian prion diseases. In many cases, prion strains manifest as variation in disease progression and pathology, and in...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Huang, Vincent J., Stein, Kevin C., True, Heather L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808357/
https://ncbi.nlm.nih.gov/pubmed/24205387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079582
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