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Regulation of the Hsp104 Middle Domain Activity Is Critical for Yeast Prion Propagation

Molecular chaperones play a significant role in preventing protein misfolding and aggregation. Indeed, some protein conformational disorders have been linked to changes in the chaperone network. Curiously, in yeast, chaperones also play a role in promoting prion maintenance and propagation. While ma...

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Detalhes bibliográficos
Main Authors: Dulle, Jennifer E., Stein, Kevin C., True, Heather L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900729/
https://ncbi.nlm.nih.gov/pubmed/24466354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087521
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