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Low activity of select Hsp104 mutants is sufficient to propagate unstable prion variants

The molecular chaperone network plays a critical role in the formation and propagation of self-replicating yeast prions. Not only do individual prions differ in their requirements for certain chaperones, but structural variants of the same prion can also display distinct dependences on the chaperone...

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Bibliografiske detaljer
Main Authors: Dulle, Jennifer E, True, Heather L
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134344/
https://ncbi.nlm.nih.gov/pubmed/24064980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.26547
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