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N-Terminal Domain of Yeast Hsp104 Chaperone Is Dispensable for Thermotolerance and Prion Propagation but Necessary for Curing Prions by Hsp104 Overexpression
Hsp104 is a hexameric protein chaperone that resolubilizes stress-damaged proteins from aggregates. Hsp104 promotes [PSI(+)] prion propagation by breaking prion aggregates, which propagate as amyloid fibers, into more numerous prion “seeds.” Inactivating Hsp104 cures cells of [PSI(+)] and other amyl...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Copyright © 2006 by the Genetics Society of America
2006
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1526498/ https://ncbi.nlm.nih.gov/pubmed/16582428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.056820 |
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