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Amino acid residue 184 of yeast Hsp104 chaperone is critical for prion-curing by guanidine, prion propagation, and thermotolerance

Inactivation of Hsp104 by guanidine is contended to be the mechanism by which guanidine cures yeast prions. We now find an Hsp104 mutation (D184N) that confers resistance to guanidine-curing of the yeast [PSI(+)] prion. In an independent screen we isolated an HSP104 allele altered in the same residu...

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Detaylı Bibliyografya
Asıl Yazarlar: Jung, Giman, Jones, Gary, Masison, Daniel C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2002
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC126603/
https://ncbi.nlm.nih.gov/pubmed/12105276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152333299
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