Amino acid residue 184 of yeast Hsp104 chaperone is critical for prion-curing by guanidine, prion propagation, and thermotolerance

Inactivation of Hsp104 by guanidine is contended to be the mechanism by which guanidine cures yeast prions. We now find an Hsp104 mutation (D184N) that confers resistance to guanidine-curing of the yeast [PSI(+)] prion. In an independent screen we isolated an HSP104 allele altered in the same residu...

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I whakaputaina i:	Proc Natl Acad Sci U S A
Ngā kaituhi matua:	Jung, Giman, Jones, Gary, Masison, Daniel C.
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	National Academy of Sciences 2002
Ngā marau:	Biological Sciences
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126603/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12105276/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.152333299
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