Antagonistic Interactions between Yeast Chaperones Hsp104 and Hsp70 in Prion Curing

The maintenance of [PSI], a prion-like form of the yeast release factor Sup35, requires a specific concentration of the chaperone protein Hsp104: either deletion or overexpression of Hsp104 will cure cells of [PSI]. A major puzzle of these studies was that overexpression of Hsp104 alone, from a hete...

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Bibliografiske detaljer
Main Authors: Newnam, Gary P., Wegrzyn, Renee D., Lindquist, Susan L., Chernoff, Yury O.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC116061/
https://ncbi.nlm.nih.gov/pubmed/9891066
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