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Yeast prion protein derivative defective in aggregate shearing and production of new ‘seeds’
According to the nucleated polymerization model, in vivo prion proliferation occurs via dissociation (shearing) of the huge prion polymers into smaller oligomeric ‘seeds’, initiating new rounds of prion replication. Here, we identify the deletion derivative of yeast prion protein Sup35 (Sup35-Δ22/69...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2001
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125771/ https://ncbi.nlm.nih.gov/pubmed/11726504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.23.6683 |
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