Yeast prion protein derivative defective in aggregate shearing and production of new ‘seeds’

According to the nucleated polymerization model, in vivo prion proliferation occurs via dissociation (shearing) of the huge prion polymers into smaller oligomeric ‘seeds’, initiating new rounds of prion replication. Here, we identify the deletion derivative of yeast prion protein Sup35 (Sup35-Δ22/69...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Borchsenius, Andrey S., Wegrzyn, Renee D., Newnam, Gary P., Inge-Vechtomov, Sergey G., Chernoff, Yury O.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125771/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11726504/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.23.6683
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