Yeast prion protein derivative defective in aggregate shearing and production of new ‘seeds’

According to the nucleated polymerization model, in vivo prion proliferation occurs via dissociation (shearing) of the huge prion polymers into smaller oligomeric ‘seeds’, initiating new rounds of prion replication. Here, we identify the deletion derivative of yeast prion protein Sup35 (Sup35-Δ22/69...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Borchsenius, Andrey S., Wegrzyn, Renee D., Newnam, Gary P., Inge-Vechtomov, Sergey G., Chernoff, Yury O.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125771/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11726504/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.23.6683
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