Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. We show here that NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential in nude mice. These changes are related to represse...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Martínez-Iglesias, Olaia A., Alonso-Merino, Elvira, Gómez-Rey, Sara, Velasco-Martín, Juan Pedro, Martín Orozco, Rosa, Luengo, Enrique, García Martín, Rosa, Ibáñez de Cáceres, Inmaculada, Fernández, Agustín F., Fraga, Mario F., González-Peramato, Pilar, Varona, Constantino, Palacios, José, Regadera, Javier, Aranda, Ana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2016
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725484/
https://ncbi.nlm.nih.gov/pubmed/26729869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520469113
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