Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. We show here that NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential in nude mice. These changes are related to represse...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Martínez-Iglesias, Olaia A., Alonso-Merino, Elvira, Gómez-Rey, Sara, Velasco-Martín, Juan Pedro, Martín Orozco, Rosa, Luengo, Enrique, García Martín, Rosa, Ibáñez de Cáceres, Inmaculada, Fernández, Agustín F., Fraga, Mario F., González-Peramato, Pilar, Varona, Constantino, Palacios, José, Regadera, Javier, Aranda, Ana
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725484/
https://ncbi.nlm.nih.gov/pubmed/26729869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520469113
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