Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. We show here that NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential in nude mice. These changes are related to represse...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Martínez-Iglesias, Olaia A., Alonso-Merino, Elvira, Gómez-Rey, Sara, Velasco-Martín, Juan Pedro, Martín Orozco, Rosa, Luengo, Enrique, García Martín, Rosa, Ibáñez de Cáceres, Inmaculada, Fernández, Agustín F., Fraga, Mario F., González-Peramato, Pilar, Varona, Constantino, Palacios, José, Regadera, Javier, Aranda, Ana
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725484/
https://ncbi.nlm.nih.gov/pubmed/26729869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520469113
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