Thyroid hormones inhibit TGF-β signaling and attenuate fibrotic responses

TGF-β, the most potent profibrogenic factor, acts by activating SMAD (mothers against decapentaplegic) transcription factors, which bind to SMAD-binding elements in target genes. Here, we show that the thyroid hormone triiodothyronine (T3), through binding to its nuclear receptors (TRs), is able to...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Alonso-Merino, Elvira, Martín Orozco, Rosa, Ruíz-Llorente, Lidia, Martínez-Iglesias, Olaia A., Velasco-Martín, Juan Pedro, Montero-Pedrazuela, Ana, Fanjul-Rodríguez, Luisa, Contreras-Jurado, Constanza, Regadera, Javier, Aranda, Ana
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914168/
https://ncbi.nlm.nih.gov/pubmed/27247403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506113113
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