Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression

Lens epithelial cells differentiate into lens fibers (LFs) in response to a fibroblast growth factor (FGF) gradient. This cell fate decision requires the transcription factor Prox1, which has been hypothesized to promote cell cycle exit in differentiating LF cells. However, we find that conditional...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Audette, Dylan S., Anand, Deepti, So, Tammy, Rubenstein, Troy B., Lachke, Salil A., Lovicu, Frank J., Duncan, Melinda K.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725344/
https://ncbi.nlm.nih.gov/pubmed/26657765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.127860
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