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β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis

PURPOSE: Previous research showed that the absence of β1-integrin from the mouse lens after embryonic day (E) 13.5 (β1MLR10) leads to the perinatal apoptosis of lens epithelial cells (LECs) resulting in severe microphthalmia. This study focuses on elucidating the molecular connections between β1-int...

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書目詳細資料
發表在:Invest Ophthalmol Vis Sci
Main Authors: Wang, Yichen, Terrell, Anne M., Riggio, Brittany A., Anand, Deepti, Lachke, Salil A., Duncan, Melinda K.
格式: Artigo
語言:Inglês
出版: The Association for Research in Vision and Ophthalmology 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539801/
https://ncbi.nlm.nih.gov/pubmed/28763805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-21721
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