β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis

PURPOSE: Previous research showed that the absence of β1-integrin from the mouse lens after embryonic day (E) 13.5 (β1MLR10) leads to the perinatal apoptosis of lens epithelial cells (LECs) resulting in severe microphthalmia. This study focuses on elucidating the molecular connections between β1-int...

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Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Wang, Yichen, Terrell, Anne M., Riggio, Brittany A., Anand, Deepti, Lachke, Salil A., Duncan, Melinda K.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2017
Subjects:
Lens
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539801/
https://ncbi.nlm.nih.gov/pubmed/28763805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-21721
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