β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis

PURPOSE: Previous research showed that the absence of β1-integrin from the mouse lens after embryonic day (E) 13.5 (β1MLR10) leads to the perinatal apoptosis of lens epithelial cells (LECs) resulting in severe microphthalmia. This study focuses on elucidating the molecular connections between β1-int...

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Veröffentlicht in:Invest Ophthalmol Vis Sci
Hauptverfasser: Wang, Yichen, Terrell, Anne M., Riggio, Brittany A., Anand, Deepti, Lachke, Salil A., Duncan, Melinda K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2017
Schlagworte:
Lens
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539801/
https://ncbi.nlm.nih.gov/pubmed/28763805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-21721
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